If you are part of the ozone world either as a practitioner or patient, you have most likely been hearing all sorts of chatter about “high dose ozone.” Sometimes this is called high dose, and sometimes it is referred to as 10-pass or multi-pass. And if you have already experienced ozone, you know what a fantastic tool it can be to treating disease, anti-aging, and athletic performance. To talk about high doses of ozone, we must first understand what a low-dose is and realize the differences. Many clinics worldwide use ozone differently, and many international organizations on ozone disagree on how to dose ozone specific indications. There is the rectal application, an IV application, and a multitude of others. We will be focusing on the IV doses of ozone. Major Autohemotherapy (MAH) is the general treatment for delivering the standard doses of ozone and differs depending on the country.

Generally, 2400-14,000 micrograms of ozone are combined with a patient’s whole blood and administered intravenously. Research going back 60 years states that these doses are safe and effective, whether administered rectally, vaginally or intravenously. Even the FDA approved the dosage through Phase II trials. Most ozone groups agree that clinically, ozone is 40- 85% effective across a broad range of conditions, symptoms, and applications, whether it is wound care, joint conditions, cardiovascular disease, or bacterial/viral conditions.There has been a new movement rising to test and administer higher doses of ozone, reaching up to 140,000 micrograms in a single treatment. Generally, a German ozone device gives the dosage by pulling blood from the patient, infusing ozone, and readministering    the now ozonated blood ten times.

Hence the name 10-Pass or Multi-Pass. Many ozone experts, such as Robert Rowan and Howard Liebowitz, MD, use the German device and technique.

Our office offers low dose ozone, high dose ozone (UVBI), 10-pass, and in October 2022, we will have a new machine called an EBOO.  To learn more, call our office!

We recommend that you do not initiate your ozone therapy with a high dose treatment, but instead, start with the lower doses of ozone first, then titrating your dose up until you reach a point to which high-dose is the next obvious step.